Mechanisms underlying the regulation of Nedd4-family E3 Ubiquitin ligases

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Dateien:
Aufrufstatistik

URI: http://hdl.handle.net/10900/79633
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-796334
http://dx.doi.org/10.15496/publikation-21031
Dokumentart: Dissertation
Date: 2020-01-10
Language: English
Faculty: 7 Mathematisch-Naturwissenschaftliche Fakultät
Department: Biochemie
Advisor: Wiesner, Silke (Dr.)
Day of Oral Examination: 2017-12-08
DDC Classifikation: 570 - Life sciences; biology
Keywords: Proteine , Magnetische Kernresonanz , Ligasen , Biochemie , Ubiquitinierung , Ubiquitin
Other Keywords:
Biochemistry
Protein
NMR
Ubiquitination
E3 ligases
Nedd4-family
License: Publishing license excluding print on demand
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Inhaltszusammenfassung:

Dissertation ist gesperrt bis 10. Januar 2020 !

Abstract:

Nedd4-family enzymes play key roles in the establishment and regulation of both developmental and carcinogenic processes. Hence, profound studies of the catalytic mechanisms and detailed analysis of protein-specific regulation of these enzymes as presented in this thesis, contribute significantly to the understanding of HECT ligases but also may have implications for the development of pharmaceutical inhibitors.

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