Browsing 4 Medizinische Fakultät by Author "Zanger, Ulrich M."

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A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

Klein, Kathrin; Tremmel, Roman; Winter, Stefan; Fehr, Sarah; Battke, Florian; Scheurenbrand, Tim; Schaeffeler, Elke; Biskup, Saskia; Schwab, Matthias; Zanger, Ulrich M. (2019)
A Systematic Comparison of the Impact of Inflammatory Signaling on Absorption, Distribution, Metabolism, and Excretion Gene Expression and Activity in Primary Human Hepatocytes and HepaRG Cells

Klein, Marcus; Thomas, Maria; Hofmann, Ute; Seehofer, Daniel; Damm, Georg; Zanger, Ulrich M. (2015)
Activating and Inhibitory Functions of WNT/beta-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells

Thomas, Maria; Bayha, Christine; Vetter, Silvia; Hofmann, Ute; Schwarz, Michael; Zanger, Ulrich M.; Braeuning, Albert (2015)
Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma

Pelle, Lucia; Cipollini, Monica; Tremmel, Roman; Romei, Cristina; Figlioli, Gisella; Gemignani, Federica; Melaiu, Ombretta; De Santi, Chiara; Barone, Elisa; Elisei, Rossella; Seiser, Eric; Innocenti, Federico; Zanger, Ulrich M.; Landi, Stefano (2016)
beta-Defensin 1 ls Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

Klag, Thomas; Thomas, Maria; Ehmann, Dirk; Courth, Lioba; Mailaender-Sanchez, Daniela; Weiss, Thomas S.; Dayoub, Rania; Abshagen, Kerstin; Vollmar, Brigitte; Thasler, Wolfgang E.; Stange, Eduard F.; Berg, Christoph P.; Malek, Nisar P.; Zanger, Ulrich M.; Wehkamp, Jan (2018)
Clinical relevance of DPYD variants c.1679T > G, c.1236G > A/HapB3, and c.1601G > A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

Meulendijks, Didier; Henricks, Linda M.; Sonke, Gabe S.; Deenen, Maarten J.; Froehlich, Tanja K.; Amstutz, Ursula; Largiader, Carlo R.; Jennings, Barbara A.; Marinaki, Anthony M.; Sanderson, Jeremy D.; Kleibl, Zdenek; Kleiblova, Petra; Schwab, Matthias; Zanger, Ulrich M.; Palles, Claire; Tomlinson, Ian; Gross, Eva; van Kuilenburg, Andre B. P.; Punt, Cornelis J. A.; Koopman, Miriam; Beijnen, Jos H.; Cats, Annemieke; Schellens, Jan H. M. (2015)
Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists

Braeuning, Albert; Thomas, Maria; Hoffmann, Ute; Vetter, Silvia; Zeller, Eva; Petzuch, Barbara; Johänning, Janina; Schroth, Werner; Weiss, Thomas S.; Zanger, Ulrich M.; Schwarz, Michael (2015)
Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression

Tremmel, Roman; Klein, Kathrin; Battke, Florian; Fehr, Sarah; Winter, Stefan; Scheurenbrand, Tim; Schaeffeler, Elke; Biskup, Saskia; Schwab, Matthias; Zanger, Ulrich M. (2020)
Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

Heintze, Tamara; Klein, Kathrin; Hofmann, Ute; Zanger, Ulrich M. (2021)
Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes; Zanger, Ulrich M.; Noren, Agneta; Wegler, Christine; Artursson, Per; Joos, Thomas O.; Poetz, Oliver (2018)
Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism

Crane, Alice L.; Klein, Kathrin; Zanger, Ulrich M.; Olson, James R. (2012)
Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Zhang, J. E.; Klein, Kathrin; Jorgensen, Andrea L.; Francis, Ben; Alfirevic, Ana; Bourgeois, Stephane; Deloukas, Panagiotis; Zanger, Ulrich M.; Pirmohamed, Munir (2017)
Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

Heintze, Tamara; Wilhelm, Denise; Schmidlin, Thierry; Hofmann, Ute; Zanger, Ulrich M.; Schwab, Matthias; Klein, Kathrin (2021)
Expression Variability of Absorption, Distribution, Metabolism, Excretion-Related MicroRNAs in Human Liver: Influence of Nongenetic Factors and Association with Gene Expressions

Rieger, Jessica K.; Klein, Kathrin; Winter, Stefan; Zanger, Ulrich M. (2013)
Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody

Emond, Jean-Philippe; Labriet, Adrien; Desjardins, Sylvie; Rouleau, Michele; Villeneuve, Lyne; Hovington, Helene; Brisson, Herve; Lacombe, Louis; Simonyan, David; Caron, Patrick; Perigny, Martine; Tetu, Bernard; Fallon, John K.; Klein, Kathrin; Smith, Philip C.; Zanger, Ulrich M.; Guillemette, Chantal; Levesque, Eric (2019)
Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1

Tremmel, R.; Klein, K.; Winter, S.; Schaeffeler, E.; Zanger, U. M. (2016)
Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens: Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis

Rosmarin, Dan; Palles, Claire; Church, David; Domingo, Enric; Jones, Angela; Johnstone, Elaine; Wang, Haitao; Love, Sharon; Julier, Patrick; Scudder, Claire; Nicholson, George; Gonzalez-Neira, Anna; Martin, Miguel; Sargent, Daniel; Green, Erin; McLeod, Howard; Zanger, Ulrich M.; Schwab, Matthias; Braun, Michael; Seymour, Matthew; Thompson, Lindsay; Lacas, Benjamin; Boige, Valerie; Ribelles, Nuria; Afzal, Shoaib; Enghusen, Henrik; Jensen, Soren Astrup; Etienne-Grimaldi, Marie-Christine; Milano, Gerard; Wadelius, Mia; Glimelius, Bengt; Garmo, Hans; Gusella, Milena; Lecomte, Thierry; Laurent-Puig, Pierre; Martinez-Balibrea, Eva; Sharma, Rohini; Garcia-Foncillas, Jesus; Kleibl, Zdenek; Morel, Alain; Pignon, Jean-Pierre; Midgley, Rachel; Kerr, David; Tomlinson, Ian (2014)
Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

Muerdter, Thomas E.; Kerb, Reinhold; Turpeinen, Miia; Schroth, Werner; Ganchev, Boian; Boehmer, Gabriele M.; Igel, Svitlana; Schaeffeler, Elke; Zanger, Ulrich; Brauch, Hiltrud; Schwab, Matthias (2012)
Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

Nies, Anne T.; Niemi, Mikko; Burk, Oliver; Winter, Stefan; Zanger, Ulrich M.; Stieger, Bruno; Schwab, Matthias; Schaeffeler, Elke (2013)
Genetics, Epigenetics, and Regulation of Drug-Metabolizing Cytochrome P450 Enzymes

Zanger, U. M.; Klein, K.; Thomas, M.; Rieger, J. K.; Tremmel, R.; Kandel, B. A.; Klein, M.; Magdy, T. (2014)

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