The Role of Cyclic Guanosine Monophosphate Signaling in Biomechanics

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The Role of Cyclic Guanosine Monophosphate Signaling in Biomechanics

Balmes, Aylin
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Zitierfähiger Link (URI): http://hdl.handle.net/10900/159802
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1598027
http://dx.doi.org/10.15496/publikation-101134
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-1598026
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-1598021
Dokumentart: Dissertation
Erscheinungsdatum: 2026-12-12
Sprache: Englisch
Fakultät: 7 Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich: Physik
Gutachter: Schäffer, Tilman (Prof. Dr.)
Tag der mündl. Prüfung: 2024-12-13
DDC-Klassifikation: 500 - Naturwissenschaften
Lizenz: http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en
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Inhaltszusammenfassung:

Die Dissertation ist gesperrt bis zum 12. Dezember 2026 !

Abstract:

Cyclic guanosine monophosphate (cGMP) is an important second messenger that is involved in the regulation of many physiological and pathological processes. The investigation of biomechanical properties (e.g. stiffness) can provide valuable insights on cell behavior. However, the influence of cGMP signaling on biomechanical properties of cells remains mostly unknown. In this thesis the role of cGMP signaling in biomechanics is investigated in platelets, vascular smooth muscle cells (VSMCs), and dorsal root ganglion (DRG) neurons. For this, different techniques were used, including atomic force microscopy (AFM), scanning ion conductance microscopy (SICM), and pulse wave velocity (PWV) measurements.

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