dc.contributor.advisor |
Zeck, Günther (Dr.) |
|
dc.contributor.author |
Lee, Meng-Jung |
|
dc.date.accessioned |
2021-03-09T07:20:54Z |
|
dc.date.available |
2021-03-09T07:20:54Z |
|
dc.date.issued |
2021-03-09 |
|
dc.identifier.other |
1750904039 |
de_DE |
dc.identifier.uri |
http://hdl.handle.net/10900/113170 |
|
dc.identifier.uri |
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1131707 |
de_DE |
dc.identifier.uri |
http://dx.doi.org/10.15496/publikation-54546 |
|
dc.description.abstract |
The mammalian retina processes sensory signals through two major pathways: a vertical excitatory pathway, which involves photoreceptors, bipolar cells and ganglion cells, and a horizontal inhibitory pathway, which involves horizontal cells and amacrine cells. This concept explains the generation of excitatory center – inhibitory surround sensory receptive fields but fails to explain modulation of the retinal output by stimuli outside the receptive field. Electrical imaging of the light-induced signal propagation at high spatial and temporal resolution across and within different retinal layers might reveal mechanisms and circuits involved in the remote modulation of the retinal output.
Here I took advantage of a high-density complementary metal-oxide semiconductor -based microelectrode array and investigated light-induced propagation of local field potentials in vertical mouse retina slices. I found that the local field potentials propagation within the different retinal layers depends on stimulus duration and stimulus background. Application of the same spatially restricted light stimuli to flat-mount retina induced ganglion cell activity at remote distances from stimulus center. This effect disappeared if a global background was provided or if gap junctions were blocked. I hereby presented a neurotechnological approach and demonstrated its application, in which electrical imaging evaluates stimulus-dependent signal processing across different neural layers. |
en |
dc.language.iso |
en |
de_DE |
dc.publisher |
Universität Tübingen |
de_DE |
dc.rights |
ubt-podok |
de_DE |
dc.rights.uri |
http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de |
de_DE |
dc.rights.uri |
http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en |
en |
dc.subject.classification |
Netzhaut , CMOS |
de_DE |
dc.subject.ddc |
500 |
de_DE |
dc.subject.other |
micro-electrode array |
en |
dc.subject.other |
electrical imaging |
en |
dc.title |
Electrical imaging of light-induced signals within and across retinal layers |
en |
dc.type |
PhDThesis |
de_DE |
dcterms.dateAccepted |
2021-01-26 |
|
utue.publikation.fachbereich |
Physik |
de_DE |
utue.publikation.fakultaet |
7 Mathematisch-Naturwissenschaftliche Fakultät |
de_DE |