Electrical imaging of light-induced signals within and across retinal layers

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dc.contributor.advisor Zeck, Günther (Dr.)
dc.contributor.author Lee, Meng-Jung
dc.date.accessioned 2021-03-09T07:20:54Z
dc.date.available 2021-03-09T07:20:54Z
dc.date.issued 2021-03-09
dc.identifier.other 1750904039 de_DE
dc.identifier.uri http://hdl.handle.net/10900/113170
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1131707 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-54546
dc.description.abstract The mammalian retina processes sensory signals through two major pathways: a vertical excitatory pathway, which involves photoreceptors, bipolar cells and ganglion cells, and a horizontal inhibitory pathway, which involves horizontal cells and amacrine cells. This concept explains the generation of excitatory center – inhibitory surround sensory receptive fields but fails to explain modulation of the retinal output by stimuli outside the receptive field. Electrical imaging of the light-induced signal propagation at high spatial and temporal resolution across and within different retinal layers might reveal mechanisms and circuits involved in the remote modulation of the retinal output. Here I took advantage of a high-density complementary metal-oxide semiconductor -based microelectrode array and investigated light-induced propagation of local field potentials in vertical mouse retina slices. I found that the local field potentials propagation within the different retinal layers depends on stimulus duration and stimulus background. Application of the same spatially restricted light stimuli to flat-mount retina induced ganglion cell activity at remote distances from stimulus center. This effect disappeared if a global background was provided or if gap junctions were blocked. I hereby presented a neurotechnological approach and demonstrated its application, in which electrical imaging evaluates stimulus-dependent signal processing across different neural layers. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Netzhaut , CMOS de_DE
dc.subject.ddc 500 de_DE
dc.subject.other micro-electrode array en
dc.subject.other electrical imaging en
dc.title Electrical imaging of light-induced signals within and across retinal layers en
dc.type Dissertation de_DE
dcterms.dateAccepted 2021-01-26
utue.publikation.fachbereich Physik de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE

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