Auflistung nach Autor "Klein, Kathrin"

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A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

Klein, Kathrin; Tremmel, Roman; Winter, Stefan; Schwab, Matthias; Zanger, Ulrich M.; Schäffeler, Elke (2019)
Bioactivation of chlorpyrifos by CYP2B6 variants.

Klein, Kathrin (2012-12)
Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia

Keulen, Jibbe; Klein, Kathrin; Büttner, Florian A.; Lauschke, Volker M. (2022)
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins

Neul, Claudia; Hofmann, Ute; Schäffeler, Elke; Winter, Stefan; Klein, Kathrin; Eichelbaum, Michel; Schwab, Matthias; Nies, Anne (2021)
Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression

Tremmel, Roman; Klein, Kathrin; Winter, Stefan; Schäffeler, Elke; Schwab, Matthias; Zanger, Ulrich M.; Battke, Florian (2020)
Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

Heintze, Tamara Sonja; Klein, Kathrin; Hofmann, Ute; Zanger, Ulrich M. (2021)
Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

Weiß, Frederik; Klein, Kathrin; Planatscher, Hannes; Zanger, Ulrich M.; Joos, Thomas; Hammer, Helen; Pötz, Oliver (2018)
Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

Klein, Kathrin; Zanger, Ulrich M. (2017)
Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

Klein, Kathrin; Nies, Anne (2021)
Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

Heintze, Tamara Sonja; Schmidlin, Thierry; Hofmann, Ute; Zanger, Ulrich M.; Schwab, Matthias; Klein, Kathrin (2021)
Expression Variability of Absorption, Distribution, Metabolism, Excretion-Related MicroRNAs in Human Liver: Influence of Nongenetic Factors and Association with Gene Expressions

Rieger, Jessica Karin; Klein, Kathrin; Winter, Stefan; Zanger, Ulrich M. (2013)
Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody

Klein, Kathrin; Zanger, Ulrich M. (2019)
Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1

Tremmel, Roman; Klein, Kathrin; Winter, Stefan; Schäffeler, Elke; Zanger, Ulrich M. (2016)
Genetics, Epigenetics, and Regulation of Drug-Metabolizing Cytochrome P450 Enzymes

Thomas, Maria; Tremmel, Roman; Kandel, Benjamin A.; Klein, Marcus; Magdy, Tarek; Zanger, Ulrich M.; Klein, Kathrin; Rieger, Jessica Karin (2014)
Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

Bonin, Michael; Schwab, Matthias; Schröder, Adrian; Zell, Andreas; Klein, Kathrin; Zanger, Ulrich M. (2013)
Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

Tremmel, Roman; Nies, Anne; Van Eijck, Barbara Adriana Charlotte; Haag, Mathias; Winter, Stefan; Büttner, Florian A.; Kölz, Charlotte; Klein, Franziska; Mazzola, Pascale; Hofmann, Ute; Klein, Kathrin; Schwab, Matthias; Schäffeler, Elke (2022)
Isoniazid Mediates the CYP2B6*6 Genotype-Dependent Interaction between Efavirenz and Antituberculosis Drug Therapy through Mechanism-Based Inactivation of CYP2A6

Klein, Kathrin; Zanger, Ulrich M. (2014)
Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450

Ryu, Chang S.; Klein, Kathrin; Zanger, Ulrich M. (2017)
Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels

Tremmel, Roman; Klein, Kathrin; Zanger, Ulrich M. (2017)
MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation

Kugler, Nicole; Klein, Kathrin; Zanger, Ulrich M. (2020)

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