The development of neoplastic transformations is characterized by persistent proliferation as well as deregulation of the apoptosis signalling pathway. Reduced apoptosis is often caused by overexpression of anti-apoptotic ...
The Bcl-2 family of proteins regulates mitochondrial outer membrane permeabilization
(MOMP) – considered as the point-of-no-return in apoptosis. As the gatekeeper for survival
or death of cells, this network is tightly ...