Identifying and characterizing transcriptional regulatory elements from chromosome conformation capture data

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dc.contributor.advisor Chan, Frank (Dr.)
dc.contributor.author Yancoskie, Michelle N.
dc.date.accessioned 2019-11-26T08:05:14Z
dc.date.available 2019-11-26T08:05:14Z
dc.date.issued 2019-11-26
dc.identifier.other 1683554825 de_DE
dc.identifier.uri http://hdl.handle.net/10900/95108
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-951085 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-36492
dc.description.abstract Which features on the chromatin are responsible for regulating gene transcription? Using promoter contacts obtained from chromosome conformation capture (3C) data as a readout for transcriptional regulation, I modeled how well histone modification marks and chromatin accessibility predict promoter contact frequency. I found that promoter contacts were often located in the same topologically associating domain and that the correlation between promoter contact frequency and each chromatin feature varied across promoter gene expression level, with poised promoters less constrained than active or silent promoters when forming contacts. I applied this knowledge to understand the molecular changes that occurred at several limb development enhancers in a mouse selective breeding experiment for longer tibia called “Longshanks." en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Transkription , Maus , DNS , Chromatin , Histone , Genexpression , Enhancer , Promotor de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.subject.other Chromosome conformation capture (3C) en
dc.subject.other chromatin structure en
dc.subject.other topologically associating domain en
dc.subject.other transcriptional regulation en
dc.subject.other cis-regulatory elements en
dc.subject.other Longshanks en
dc.subject.other limb development en
dc.subject.other ANCOVA en
dc.title Identifying and characterizing transcriptional regulatory elements from chromosome conformation capture data en
dc.type Dissertation de_DE
dcterms.dateAccepted 2019-11-05
utue.publikation.fachbereich Biologie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE

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