Entwicklung und Charakterisierung von gefriergetrockneten Tabletten mittels Lyoc® Technologie

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dc.contributor.advisor Daniels, Rolf (Prof. Dr.)
dc.contributor.author Hernandez, Faustine
dc.date.accessioned 2019-05-28T05:13:20Z
dc.date.available 2019-05-28T05:13:20Z
dc.date.issued 2019-05-28
dc.identifier.other 1666423254 de_DE
dc.identifier.uri http://hdl.handle.net/10900/88950
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-889502 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-30331
dc.description.abstract The goal of this dissertation was to characterize and optimize the formulation of lyophilized Orally Disintegrating Tablets (ODTs), by using more specifically the patented Lyoc® technology. ODTs have several advantages in comparison to conventional tablets, since they allow the patient to have a convenient administration (no need of water, discreet treatment, does not leave any residue in the mouth after administration). This dosage form is thus adapted for patients who have swallowing difficulties (such as pediatric use, geriatric use, and patients suffering from dysphagia), and has a great area of interest for the psychiatric use. A Lyoc® formulation is based on a suspension system containing mainly a diluent, a binder, Active Pharmaceutical Ingredient (API) and water. In the frame of the formulation development, a Design of Experiment study was performed on a Mannitol / Dextran / Water formulation and revealed that even if the studied systems were quite complex due to the broad ranges of IPCs and the high variability possibility of each compound, an optimum could still be successfully determined. The API solubility also has an influence on the Lyocs® not only on the macroscopic but also on the microscopic structure of the Lyocs®. Using X-Ray and DSC Analysis, it could be stated that water-soluble APIs tended to get partially amorphous after lyophilization, leading to a structure loss. On the contrary, less water-soluble APIs stays crystalline after lyophilization, which imparts elegance to the Lyoc® structure. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en en
dc.subject.classification Gefriertrocknung , Schmelztablette , O.D.T. , Formulierung de_DE
dc.subject.ddc 500 de_DE
dc.title Entwicklung und Charakterisierung von gefriergetrockneten Tabletten mittels Lyoc® Technologie de_DE
dc.type Dissertation de_DE
dcterms.dateAccepted 2019-04-23
utue.publikation.fachbereich Pharmazie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE

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