Electro/magnetoencephalographic signatures of human brain insulin resistance

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URI: http://hdl.handle.net/10900/86715
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-867154
http://dx.doi.org/10.15496/publikation-28102
Dokumentart: Aufsatz
Date: 2016-06
Source: Current Opinion in Behavioral Sciences 2016, 9:163–168
Language: English
Faculty: 4 Medizinische Fakultät
Department: Medizin
DDC Classifikation: 500 - Natural sciences and mathematics
Keywords: Insulin
License: Publishing license excluding print on demand
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Abstract:

Human insulin action influences eating behavior, peripheral metabolism and cognition. Detailed insights into the neuronal processes related to human brain insulin action can be obtained by direct measures of neuronal activity with electroencephalography and magnetoencephalography. Results of recent studies show that spontaneous, task and stimulus related neuronal activity is modulated by insulin and that several factors like increased body weight and body composition can result in brain insulin resistance. Recent technological advances even allow the investigation of human brain functions in utero in relation to the metabolic status of the mother and indicate an effect of the mother’s insulin sensitivity on the brain function of the fetus. In conclusion, studies based on direct neuronal measurements may help to determine the developmental trajectory related to insulin action and resistance.

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