Characterizing the molecular signatures induced by oncolytic measles virus along with conventional therapies in experimental glioma

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Dokumentart: PhDThesis
Date: 2020-12-18
Language: English
Faculty: 4 Medizinische Fakultät
Department: Medizin
Advisor: Tabatabai, Ghazaleh (Prof. Dr. Dr.)
Day of Oral Examination: 2018-12-18
DDC Classifikation: 570 - Life sciences; biology
610 - Medicine and health
Keywords: Gliom , Masern , Synergie
Other Keywords:
oncolytic measles virus
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Scientific Objectives 1. To determine the feasibility of oncolytic virotherapy using MeV in glioblastoma through characterization of glioma cell lines and primary glioblastoma cell cultures in vitro. 2. To identify a synergistic combination of MeV with SOC, radiotherapy and alkylating chemotherapy in glioma cell lines (LN229 and LNZ308), glioma stem-like cells (GS8) and temozolomide-resistant LN229 cells (R-LN229) in vitro. 3. To characterize and validate the molecular mechanisms of synergy in the combinatorial treatment regimen through transcriptome analysis using RNA sequencing. 4. To delineate the treatment-induced immunological profile of MeV-infected glioma cells established through presentation of antigens using HLA ligandome analysis.

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