Single-Voxel Proton Magnetic Resonance Spectroscopy in the Human Brain at 9.4 T: Methods and Applications

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dc.contributor.advisor Henning, Anke (Prof. Dr.) Giapitzakis, Ioannis-Angelos 2018-05-18T05:43:03Z 2018-05-18T05:43:03Z 2018-05-18
dc.identifier.other 505286513 de_DE
dc.identifier.uri de_DE
dc.description.abstract Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive method allowing the detection as well as the quantification of several metabolites in the human brain. The introduction of ultra-high field (UHF) scanners (≥7 T) led to an increase of the signal-to-noise ratio and a higher frequency dispersion, hence better spectral resolution. These advantages promote the potential of MRS. Despite the significant advantages of UHF for MRS, several technical challenges (such as B1+efficiency and inhomogeneity, increased power deposition, chemical shift displacement etc.) must be addressed for the efficient utilization of these prospective benefits. The methods and techniques developed during this Ph.D. demonstrated the feasibility of metabolite cycling (MC) at 9.4 T, and the advantages of non-water suppressed MRS regarding frequency and phase fluctuations. The newly developed sequences (MC-STEAM and MC-semi-LASER) enabled the acquisition of reliable spectra with enhanced frequency resolution, both upfield and downfield of water in 1H spectra. Furthermore, the designed RF coils, hardware setup (power splitters, phase cables, etc.), as well as, the gained knowledge regarding the achievement of efficient transmit fields and can be utilized in future MRS studies and applications. As a result, the human brain macromolecular baseline was investigated revealing additional macromolecular peaks and information regarding their concentration levels. Moreover, the chemical exchange rates of the downfield metabolites, as well as, their correlation with the upfield peaks were examined contributing further to the assignment of the downfield peaks. Finally, the performed functional MRS studies in which the MC-semi-LASER sequences were used, demonstrated the potentials of UHF and MC regarding the simultaneous investigation of water and metabolites alterations during visual stimulation. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Magnetische Resonanz , Kernspintomografie , Metabolit de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 530 de_DE
dc.subject.ddc 570 de_DE
dc.subject.ddc 600 de_DE
dc.subject.other MR Spectroscopy en
dc.subject.other Ultra High Field MRI en
dc.subject.other Proton MRS en
dc.subject.other Non water suppressed MRS en
dc.subject.other Functional MRS en
dc.subject.other Metabolite Cycling en
dc.title Single-Voxel Proton Magnetic Resonance Spectroscopy in the Human Brain at 9.4 T: Methods and Applications en
dc.type Dissertation de_DE
dcterms.dateAccepted 2018-05-03
utue.publikation.fachbereich Graduiertenkollegs de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE


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