Erfahrungen mit der intraoperativen Magnetresonanztomographie in Tübingen mit speziellem Fokus auf intraoperatives elektrophysilogisches Monitoring

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Dokumentart: Dissertation
Date: 2018
Language: German
Faculty: 4 Medizinische Fakultät
Department: Medizin
Advisor: Roder, Constantin (PD Dr.)
Day of Oral Examination: 2018-02-22
DDC Classifikation: 610 - Medicine and health
Keywords: Neurochirurgie
License: Publishing license including print on demand
Order a printed copy: Print-on-Demand
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Objective: To show that the combined use of intraoperative high-field MRI (iMRI) and electrophysiological monitoring (IOM) is feasible, safe and beneficial for patients. Methods: The setup, surgical, imaging and clinical results of 110 patients with eloquent intracranial lesions with the combined use of 1.5T iMRI and IOM were analyzed. Results: 187 iMRI scans were performed with IOM needles in place, resulting in a total experience of using more than 4000 electrodes in the iMRI. No complication (ferromagnetic or relevant heating/burning of skin) was caused by the combined use of both technologies. Surgically induced severe postoperative sensorimotor deficits were seen in in 11.8%. The surgeon’s estimation of a “complete resection” proved to be true postoperatively in 90.3%. If the resection was stopped due to worsening of IOM, postoperative MRI revealed residual disease to be located in direct vicinity of eloquence in 27 of 28 cases, but not in other parts of the resection cavity. Of these patients, only 7% (2 of 28) had relevant new deficits after 3 months. In 82 (74.5%) of all patients the resection was continued after the iMRI scan, whereat in only 18 (16.4%) the resection was already completed at this point. Conclusion: The combined use of IOM and 1.5T iMRI is feasible and safe. The complementary use of both technologies might result in more radical resections at comparable surgically-induced neurological deficits. If available and indicated, the combined use of IOM and iMRI should be performed on a routine basis.

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