Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

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Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Author: Gunther, Marcel; Lategahn, Jonas; Juchum, Michael; Doring, Eva; Keul, Marina; Engel, Julian; Tumbrink, Hannah L.; Rauh, Daniel; Laufer, Stefan
Tübinger Autor(en):
Juchum, Michael
Laufer, Stefan
Günther, Marcel Benjamin
Döring, Eva
Published in: Journal of Medicinal Chemistry (2017), Bd. 60, H. 13, S. 5613-5637
Verlagsangabe: Amer Chemical Soc
Language: English
Full text: http://dx.doi.org/10.1021/acs.jmedchem.7b00316
ISSN: 1520-4804
DDC Classifikation: 540 - Chemistry and allied sciences
Dokumentart: Article
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