Individualization of the Immunosuppressive Therapy in Patients of Renal Transplantations through Pharmacodynamic and Pharmacogenetic Biomarkers

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dc.contributor.advisor Wieland, Eberhard (Prof. Dr.)
dc.contributor.author Abdel-Kahaar Eldardir Ahmed, Emaad
dc.date.accessioned 2017-03-07T13:32:43Z
dc.date.available 2017-03-07T13:32:43Z
dc.date.issued 2017
dc.identifier.other 485247763 de_DE
dc.identifier.uri http://hdl.handle.net/10900/74723
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-747230 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-16126
dc.description.abstract The aim of this work was to look for specific biomarkers that could help to guide therapy with immunosuppressive drugs after organ transplantation. This work entailed the analytical validation of two pharmacodynamic biomarker assays. These include “NFAT-regulated gene expression assay” to monitor therapy with calcineurin inhibitors and “phosphoflow assay of S6RP” to monitor therapy with mTOR inhibitors. Additionally, a retrospective pharmacogenetic study to investigate the frequency and the impact of 6 SNPs in the genes of CYP450 and ABAB1 on tacrolimus pharmacokinetics early after transplantation in a cohort of 121 renal transplant recipients was also conducted. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Pharmakologie , Transplantation de_DE
dc.subject.ddc 610 de_DE
dc.subject.other Immunosuppressive drugs en
dc.subject.other organ transplantation en
dc.title Individualization of the Immunosuppressive Therapy in Patients of Renal Transplantations through Pharmacodynamic and Pharmacogenetic Biomarkers en
dc.type Dissertation de_DE
dcterms.dateAccepted 2017-02-10
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE

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