Nasale High – Flow - Sauerstofftherapie bei Patienten mit hypoxischem Lungenversagen : Einfluss auf funktionelle und subjektive Atmungsparameter im Vergleich zur konventionellen O2-Therapie und zur nicht-invasiven Beatmung

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dc.contributor.advisor Riessen, Reimer (Prof. Dr.)
dc.contributor.author Berg, Björn Ulf Ralf
dc.date.accessioned 2015-09-17T10:01:17Z
dc.date.available 2015-09-17T10:01:17Z
dc.date.issued 2015-09
dc.identifier.other 445494212 de_DE
dc.identifier.uri http://hdl.handle.net/10900/64898
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-648982 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-6318
dc.description.abstract Background: Aim of the study was to compare the short-term effects of oxygen therapy via a high-flow nasal cannula (HFNC) on functional and subjective respiratory parameters in patients with acute hypoxic respiratory failure in comparison to non-invasive ventilation (NIV) and standard treatment via a Venturi mask. Methods: Fourteen patients with acute hypoxic respiratory failure were treated with HFNC (FiO2 0.6, gas flow 55 l/min), NIV (FiO2 0.6, PEEP 5 cm H2O Hg, tidal volume 6–8 ml/kg ideal body weight,) and Venturi mask (FiO2 0.6, oxygen flow 15 l/min,) in a randomized order for 30 min each. Data collection included objective respiratory and circulatory parameters as well as a subjective rating of dyspnea and discomfort by the patients on a 10-point scale. In a final interview, all three methods were comparatively evaluated by each patient using a scale from 1 (=very good) to 6 (=failed) and the patients were asked to choose one method for further treatment. Results: PaO2 was highest under NIV (129 ± 38 mmHg) compared to HFNC (101 ± 34 mmHg, p <0.01 vs. NIV) and VM (85 ± 21 mmHg, p <0.001 vs. NIV, p <0.01 vs. HFNC, ANOVA). All other functional parameters showed no relevant differences. In contrast, dyspnea was significantly better using a HFNC (2.9 ± 2.1, 10-point Borg scale) compared to NIV (5.0 ± 3.3, p <0.05), whereas dyspnea rating under HFNC and VM (3.3 ± 2.3) was not significantly different. A similar pattern was found when patients rated their overall discomfort on the 10 point scale: HFNC 2.7 ± 1.8, VM 3.1 ± 2.8 (ns vs. HFNC), NIV 5.4 ± 3.1 (p <0.05 vs. HFNC). In the final evaluation patients gave the best ratings to HFNC 2.3 ± 1.4, followed by VM 3.2 ± 1.7 (ns vs. HFNC) and NIV 4.5 ± 1.7 (p <0.01 vs. HFNC and p <0.05 vs. VM). For further treatment 10 patients chose HFNC, three VM and one NIV. Conclusions: In hypoxic respiratory failure HFNC offers a good balance between oxygenation and comfort compared to NIV and Venturi mask and seems to be well tolerated by patients. en
dc.language.iso de de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Sauerstoffbehandlung de_DE
dc.subject.ddc 610 de_DE
dc.subject.other nasal highflow oxygentherapy en
dc.subject.other respiratory failure en
dc.subject.other Optiflow de_DE
dc.subject.other Respiratorische Insuffizienz de_DE
dc.subject.other High-Flow-Sauerstofftherapie de_DE
dc.title Nasale High – Flow - Sauerstofftherapie bei Patienten mit hypoxischem Lungenversagen : Einfluss auf funktionelle und subjektive Atmungsparameter im Vergleich zur konventionellen O2-Therapie und zur nicht-invasiven Beatmung de_DE
dc.type Dissertation de_DE
dcterms.dateAccepted 2015-09-03
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.source erschienen in: BMC Anesthesiology 14: 66 de_DE

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