Neurotoxizität und Langzeitauswirkungen auf die Lebensqualität durch adjuvante Taxantherapie bei Mammakarzinom

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dc.contributor.advisor Heidemann, Else (Prof. Dr.)
dc.contributor.author Ilin, Elena
dc.date.accessioned 2015-02-20T11:14:36Z
dc.date.available 2015-02-20T11:14:36Z
dc.date.issued 2015-02
dc.identifier.other 426570642 de_DE
dc.identifier.uri http://hdl.handle.net/10900/59738
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-597386 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-1162
dc.description.abstract Neurotoxicity and long-term influence of adjuvant taxane treatment on the quality of life in primary breast cancer Ilin E.1, Rössle S.1, Meisner C. 2, Junack C.1, Stumpp C.1, Breiter S.1, Brinkmann F.1, Heidemann E.1 1 Oncological Comprehensive Center Stuttgart 2 Institute of Clinical Epidemiology and Applied Biometry, University of Tuebingen Background: The increasing use of taxanes in adjuvant chemotherapies in primary breast cancer leads to an increasing occurrence of neuropathies. Long-term data collections are lacking. Methods: 449 Patients taking part in the follow-up control programme of the Oncological Comprehensive Center Stuttgart and who had received an adjuvant chemotherapy between 2004 and 2011 were asked to fill in the EORTC QLQ C-30-questionnaire and the Patient Neurotoxicity Questionnaire (PNQ). Results: We received 304 answers. 152 patients had been treated with a taxane, 28 (18.4%) of those reported a persistent peripheral sensory neuropathy (PPSN). Of 142 patients without taxane treatment 15 (10.6%) reported a PPSN (p=0,057). The evaluation of the EORTC QLQ C-30-questionnaires did not reveal any differences between the two groups. Conclusion: Although a significant peripheral sensory neuropathy of up to 7 years has been observed in the taxane-group, this seems to have no effect on the quality of live. en
dc.language.iso de de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification Adjuvante Chemotherapie de_DE
dc.subject.ddc 610 de_DE
dc.subject.other Taxan-Chemotherapie de_DE
dc.subject.other Neurotoxizität nach Taxan-Chemotherapie de_DE
dc.title Neurotoxizität und Langzeitauswirkungen auf die Lebensqualität durch adjuvante Taxantherapie bei Mammakarzinom de_DE
dc.type Dissertation de_DE
dcterms.dateAccepted 2015-01-09
utue.publikation.fachbereich Zahnmedizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE

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