The role of the budding yeast RNA-binding proteins Khd1p and Loc1p in mRNA targeting

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Dokumentart: PhDThesis
Date: 2014-10-02
Language: English
Faculty: 7 Mathematisch-Naturwissenschaftliche Fakultät
Department: Biochemie
Advisor: Jansen, Ralf-Peter (Prof. Dr.)
Day of Oral Examination: 2014-09-26
DDC Classifikation: 570 - Life sciences; biology
Keywords: Messenger RNA
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mRNA localization is the common mechanism used by the cells to attain polarity and cellular asymmetry. In this work, I was focused on two RNA-binding proteins that involve in ASH1 mRNA localization in budding yeast. Khd1p associates with more than 1000 mRNA targets. Majority of them code for cell wall and secretory proteins. My results suggest that it has the potential to associate with endoplasmic reticulum (ER) and it is required for targeting of MID2 mRNA to ER. Loc1p is involved in the formation of nuclear ASH1-mRNP complex. During nuclear export, it is displaced by the She2p-She3p complex.

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