Fullerene-based Biocomponents : New Concepts For Functionalising Membranes

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dc.contributor Universität Erlangen-Nürnberg, Institut für Organische Chemie LS II, Henkestr. 42, D-91054 Erlangen de_CH
dc.contributor Institut für Physikalische und Theoretische Chemie de_DE
dc.contributor.author Braun, Martin de_DE
dc.contributor.author Maierhofer, Andreas P. de_DE
dc.contributor.author Danner, Birgit de_DE
dc.contributor.author Bayerl, Thomas M. de_DE
dc.contributor.author Vostrowsky, Otto de_DE
dc.contributor.author Hirsch, Andreas de_DE
dc.contributor.other Gauglitz, Günter de_DE
dc.date.accessioned 2002-05-21 de_DE
dc.date.accessioned 2014-03-18T10:10:05Z
dc.date.available 2002-05-21 de_DE
dc.date.available 2014-03-18T10:10:05Z
dc.date.issued 2002 de_DE
dc.identifier.other 099876655 de_DE
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-opus-4946 de_DE
dc.identifier.uri http://hdl.handle.net/10900/48357
dc.description.abstract Lipophilic hexakisadducts of fullerene C60 form unprecedented rod-like nanoaggregates in phospholipid-membrane bilayers, resulting in modification of the micromechanic properties and stabilisation of the membrane. Lipofullerenes with amphiphilic side chains enable additionally derivatisation and molecular recognition at the membrane surface. The amphiphilic spacer acts as a transmembrane anchor and provides the terminal functionality outside of the membrane. New systems derived from parent compound 3 carry two functional groups each and can be easily modified due to the modular synthesis. Terminal functionalities to be investigated include D(+)-biotin and IDA (iminodiacetic acid) ligands, as used in nickel-histidine tags. Modification of the lipophilic region, for instance with unsaturated addends is also possible. These addends should allow polymerisation inside the membrane and potentially lead to a tremendous increase of the membrane rigidity. Furthermore, mono- and bilayer-forming fullerene derivatives without the membrane-forming support of lecithins are investigated and exhibit interesting features. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-nopod de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ubt-nopod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ubt-nopod.php?la=en en
dc.subject.classification Biosensor , Fullerene , Lipide / Doppelschicht , Nanostruktur de_DE
dc.subject.ddc 540 de_DE
dc.subject.other biosensor , fullerene , lipid bilayer , nanoaggragates , artificial membranes en
dc.title Fullerene-based Biocomponents : New Concepts For Functionalising Membranes en
dc.type ConferenceObject de_DE
dc.date.updated 2005-01-13 de_DE
utue.publikation.fachbereich Sonstige - Chemie und Pharmazie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
dcterms.DCMIType Text de_DE
utue.publikation.typ conferenceObject de_DE
utue.opus.id 494 de_DE
utue.publikation.source http://barolo.ipc.uni-tuebingen.de/biosensor2001/ de_DE


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