Biosensors based on SPR Imaging

Abstract

Surface plasmon resonance (SPR) belongs to the most sensitive detection methods and has been used for more than 20 years to study a variety of chemical and biochemical sensor developments. Now, with the recent introduction of biochips, SPR as a label-free technology for monitoring biomolecular interactions is a promising technique for rapid and parallel detection. SPR imaging using fast optical array detectors permits simultaneous measurements across an array of immobilized molecules. SPR imaging provides excellent spatial resolution at the same sensitivity as classical SPR. These features make SPR imaging a promising detection technology for biochips.