An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies

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An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies

Prokofyeva, Elena; Wilke, Robert; Lotz, Gunnar; Troeger, Eric; Strasser, Torsten; Zrenner, Eberhart
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URI: http://nbn-resolving.de/urn:nbn:de:bsz:21-opus-56979
http://hdl.handle.net/10900/45866
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-458669
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-458662
Dokumentart: WorkingPaper
Date: 2009
Source: Prokofyeva, E., Wilke, R., Lotz, G., Troeger, E., Strasser, T. and Zrenner, E. (2009). An epidemiological approach for the estimation of disease onset in Central Europe in central and peripheral monogenic retinal dystrophies. Graefes Arch Clin Exp Ophthalmol 247, 885-894.
Language: English
Faculty: 4 Medizinische Fakultät
Department: Medizin
DDC Classifikation: 610 - Medicine and health
Keywords: Netzhaut , Epidemiologie
Other Keywords:
Hereditary retinal dystrophies , Disease onset , Epidemiology , Frequency of the disease , Blindness , Central Europe
License: http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en
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Abstract:

PURPOSE: To study clinical patterns of disease onset in monogenic retinal dystrophies (MRD), using an epidemiological approach. METHODS: Records of patients with MRD, seen at the University Eye Hospital Tuebingen from 1994 to 1999, were selected from a database and retrospectively reviewed. For analysis, patients were divided into 2 groups by predominant part of visual field (VF) involvement: group 1 (predominantly central involvement) included Stargardt disease (ST), macular dystrophy (MD), and central areolar choroidal dystrophy (CACD), and group 2 (predominantly peripheral involvement) included Bardet-Biedl syndrome (BBD), Usher syndrome (USH) I and II, and choroideremia (CHD). Age, sex, age of first diagnosis, age of visual acuity (VA) decrease and VF emergence, night blindness and photophobia onset, types of VF defects and age of its onset, color discrimination

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