MLKL activity requires a splicing-regulated, druggable intramolecular interaction

Ros, Uris; Martinez-Osorio, Veronica; Valiente, Pedro A.; Abdelwahab, Yasmin; Gojkovic, Milos; Shalaby, Raed; Zanna, Silvia; Saggau, Julia; Wachsmuth, Laurens; Nemade, Harshal N.; Zoeller, Jonathan; Lottermoser, Hannah; Chen, Yu-Guang; Ibrahim, Mohamed; Kelepouras, Konstantinos; Vasilikos, Lazaros; Bedoya, Paula; Espiritu, Rafael A.; Mueller, Stefan; Altmannova, Veronika; Tieleman, D. Peter; Weir, John; Langer, Julian; Adam, Matti; Walczak, Henning; Wong, W. Wei-Lynn; Liccardi, Gianmaria; Mollenhauer, Martin; Pasparakis, Manolis; Peltzer, Nieves; Garcia-Saez, Ana J.

MLKL activity requires a splicing-regulated, druggable intramolecular interaction

Author:

Ros, Uris; Martinez-Osorio, Veronica; Valiente, Pedro A.; Abdelwahab, Yasmin; Gojkovic, Milos; Shalaby, Raed; Zanna, Silvia; Saggau, Julia; Wachsmuth, Laurens; Nemade, Harshal N.; Zoeller, Jonathan; Lottermoser, Hannah; Chen, Yu-Guang; Ibrahim, Mohamed; Kelepouras, Konstantinos; Vasilikos, Lazaros; Bedoya, Paula; Espiritu, Rafael A.; Mueller, Stefan; Altmannova, Veronika; Tieleman, D. Peter; Weir, John; Langer, Julian; Adam, Matti; Walczak, Henning; Wong, W. Wei-Lynn; Liccardi, Gianmaria; Mollenhauer, Martin; Pasparakis, Manolis; Peltzer, Nieves; Garcia-Saez, Ana J.

Tübinger Autor(en):

Altmannova, Veronika
Espiritu, Rafael
Weir, John Russell

Published in:

Molecular Cell (2025), Bd. 85, H. 8

Verlagsangabe:

Cambridge : Cell Press

Language:

English

Full text:

http://dx.doi.org/10.1016/j.molcel.2025.03.015

ISSN:

1097-2765