Objektive Quantifizierung von Rigor bei Morbus Parkinson und tiefer Hirnstimulation mit Schwerwellenelastographie

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URI: http://hdl.handle.net/10900/160278
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-1602786
http://dx.doi.org/10.15496/publikation-101610
Dokumentart: PhDThesis
Date: 2025-01-20
Language: German
Faculty: 4 Medizinische Fakultät
Department: Medizin
Advisor: Grimm, Alexander (Prof. Dr.)
Day of Oral Examination: 2024-12-12
DDC Classifikation: 610 - Medicine and health
Keywords: Parkinson-Krankheit , Elastographie , Hirnstimulation , Neurologie , Ultraschall
Other Keywords: Scherwellenultraschall
shear wave ultrasound
License: http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en
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Abstract:

Rigidity in Parkinson’s disease (PD) is assessed by clinical scales, mostly the Unified Parkinson’s Disease Rating Scale of the Movement Disorders Society (MDS-UPDRS). While the MDS-UPDRS-III ranges on an integer scale from 0 to 4, we investigated whether muscle ultrasound shear wave elastography (SWE) offers a refined assessment. Ten PD patients (five treated with deep brain stimulation (DBS) and levodopa, five with levodopa only) and ten healthy controls were included. Over a period of 80 minutes, both the SWE value and item 22b-c of the MDS-UPDRS-III were measured at 5-minute intervals. The measurements were performed bilaterally at the biceps brachii muscle (BB) and flexor digitorum profundus muscle in flexion and passive extension. Rigidity was modified and tracked under various therapeutic conditions (with and without medication/DBS). The feasibility of SWE for objective quantification was evaluated by correlation with the UPDRS-III: considering all positions and muscles, there was a weak correlation (r = 0.01, p < 0.001)—in a targeted analysis, the BB in passive extension showed a markedly higher correlation (r = 0.494, p < 0.001). The application of dopaminergic medication and DBS resulted in statistically significant short-term changes in both clinical rigidity and SWE measurements in the BB (p < 0.001). We conclude that rigidity is reflected in the SWE measurements, indicating that SWE is a potential non-invasive quantitative assessment tool for PD.

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