Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Gomes, Lucas Caldi; Haenzelmann, Sonja; Hausmann, Fabian; Khatri, Robin; Oller, Sergio; Parvaz, Mojan; Tzeplaeff, Laura; Pasetto, Laura; Gebelin, Marie; Ebbing, Melanie; Holzapfel, Constantin; Columbro, Stefano Fabrizio; Scozzari, Serena; Knoeferle, Johanna; Cordts, Isabell; Demleitner, Antonia F.; Deschauer, Marcus; Dufke, Claudia; Sturm, Marc; Zhou, Qihui; Zelina, Pavol; Sudria-Lopez, Emma; Haack, Tobias B.; Streb, Sebastian; Kuzma-Kozakiewicz, Magdalena; Edbauer, Dieter; Pasterkamp, R. Jeroen; Laczko, Endre; Rehrauer, Hubert; Schlapbach, Ralph; Carapito, Christine; Bonetto, Valentina; Bonn, Stefan; Lingor, Paul

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

Author:

Gomes, Lucas Caldi; Haenzelmann, Sonja; Hausmann, Fabian; Khatri, Robin; Oller, Sergio; Parvaz, Mojan; Tzeplaeff, Laura; Pasetto, Laura; Gebelin, Marie; Ebbing, Melanie; Holzapfel, Constantin; Columbro, Stefano Fabrizio; Scozzari, Serena; Knoeferle, Johanna; Cordts, Isabell; Demleitner, Antonia F.; Deschauer, Marcus; Dufke, Claudia; Sturm, Marc; Zhou, Qihui; Zelina, Pavol; Sudria-Lopez, Emma; Haack, Tobias B.; Streb, Sebastian; Kuzma-Kozakiewicz, Magdalena; Edbauer, Dieter; Pasterkamp, R. Jeroen; Laczko, Endre; Rehrauer, Hubert; Schlapbach, Ralph; Carapito, Christine; Bonetto, Valentina; Bonn, Stefan; Lingor, Paul

Tübinger Autor(en):

Dufke, Claudia
Sturm, Marc
Haack, Tobias

Published in:

Nature Communications (2024), Bd. 15 (1), Article 4893

Verlagsangabe:

Berlin : Nature Portfolio

Language:

English

Full text:

http://dx.doi.org/10.1038/s41467-024-49196-y

ISSN:

2041-1723