Modelling Sensory Innervation of Cancer Using Organ-on-Chip Technology

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dc.contributor.advisor Loskill, Peter (Prof. Dr.)
dc.contributor.author van der Moolen, Matthijs L.
dc.date.accessioned 2024-08-06T11:21:42Z
dc.date.available 2024-08-06T11:21:42Z
dc.date.issued 24-08-06
dc.identifier.uri http://hdl.handle.net/10900/156253
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1562537 de_DE
dc.description.abstract Research contained in this thesis focuses on the advancement of organ-on-chip technology for the exploration of peripheral sensory innervation in cancer. Simultaneously, it describes an extensive attempt at creating a practical platform that can be leveraged to uncover novel approaches in combating cancer-induced pain and gain insight into the intricate relationship between diseased tissues and pain development at a cellular level. Development of this platform is also expected to produce a versatile system capable of addressing the often-neglected importance of peripheral innervation of various kinds in various organs and tissues. Peripheral nerves are essential in modulating tissue responses to environmental changes and maintaining tissue homeostasis, consequently, when innervation maladapts in conditions such as cancer, it has been associated with the development of pain states and tissue dysfunction. Having a technology that can accurately replicate these processes could prove valuable in facilitating the development of therapeutics aimed at alleviating pain and restoring tissue integrity. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en en
dc.subject.ddc 000 de_DE
dc.subject.ddc 420 de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 610 de_DE
dc.subject.other Organ-on-Chip en
dc.subject.other Pain en
dc.subject.other Microfabrication en
dc.subject.other Cancer en
dc.subject.other In Vitro en
dc.subject.other Neuroscience en
dc.title Modelling Sensory Innervation of Cancer Using Organ-on-Chip Technology de_DE
dc.type PhDThesis de_DE
dcterms.dateAccepted 24-07-19
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.noppn yes de_DE

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