Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Steinebach, Christian; Bricelj, Alesa; Murgai, Arunima; Sosic, Izidor; Bischof, Luca; Ng, Yuen Lam Dora; Heim, Christopher; Maiwald, Samuel; Proj, Matic; Voget, Rabea; Feller, Felix; Kosmrlj, Janez; Sapozhnikova, Valeriia; Schmidt, Annika; Zuleeg, Maximilian Rudolf; Lemnitzer, Patricia; Mertins, Philipp; Hansen, Finn K.; Guetschow, Michael; Kroenke, Jan; Hartmann, Marcus D.

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Author:

Steinebach, Christian; Bricelj, Alesa; Murgai, Arunima; Sosic, Izidor; Bischof, Luca; Ng, Yuen Lam Dora; Heim, Christopher; Maiwald, Samuel; Proj, Matic; Voget, Rabea; Feller, Felix; Kosmrlj, Janez; Sapozhnikova, Valeriia; Schmidt, Annika; Zuleeg, Maximilian Rudolf; Lemnitzer, Patricia; Mertins, Philipp; Hansen, Finn K.; Guetschow, Michael; Kroenke, Jan; Hartmann, Marcus D.

Tübinger Autor(en):

Hartmann, Marcus

Published in:

Journal of Medicinal Chemistry (2023), Bd. 66, H. 21, S. 14513-14543

Verlagsangabe:

Washington : Amer Chemical Soc

Language:

English

Full text:

http://dx.doi.org/10.1021/acs.jmedchem.3c00851

ISSN:

0022-2623