Modeling and Measurement of Tissue Compartments with Fast Signal Decay in Whole-Body Magnetic Resonance Imaging

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dc.contributor.advisor Schick, Fritz (Prof. Dr. Dr.) Fischer, Anja Maria 2023-05-11T13:30:54Z 2023-05-11T13:30:54Z 2024-05-01
dc.identifier.uri de_DE
dc.description.abstract Die Dissertation ist gesperrt bis zum 01. Mai 2024 ! de_DE
dc.description.abstract The aim of this thesis is to characterize the signal behavior of tissue components with fast signal decay in whole-body magnetic resonance imaging. Therefore, the first chapter contains a summary of the physical basics of magnetic resonance. In the following second chapter, the modeling of a possible water signal in inflamed adipose tissue is performed. For this purpose, the characteristic geometry of the water inclusions located between adipocytes is exploited to draw conclusions about the relaxation behavior and, thus, the measurability of the water signal by means of simulations and phantom measurements. It can be concluded that short echo times are necessary for detection of these fast-relaxing components. This is provided, for example, by a newly introduced method in the third chapter, which allows for the calculation of spectra based on specific imaging data sets with ultra-short echo times. Based on this approach, a characterization of the collagen signal is performed. With the resulting signal model, collagen in aqueous solution can be detected starting at a mass fraction of 2-4%. These values are attributable to a range which would be relevant, for example, for the staging of fibrosis in liver tissue. The method of calculating spatially resolved spectra using ultra-short echo times is also applied in the fourth chapter. In this chapter, modeling of the water signal originating from compact bone is performed. Thereby, different compartments can be distinguished. Usually, bound water is separated from free water present in porous structures. This typically results due to the different relaxation times of the compartments. In this section, it is postulated that the free water can be further subdivided into signal components with different frequencies based on the geometry of the shaping structures. This hypothesis is tested using the newly proposed method. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Kernspintomografie , Medizinische Physik de_DE
dc.subject.ddc 530 de_DE
dc.subject.other Magnetic Resonance Imaging en
dc.title Modeling and Measurement of Tissue Compartments with Fast Signal Decay in Whole-Body Magnetic Resonance Imaging en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2023-05-04
utue.publikation.fachbereich Physik de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.source Zeitschrift für Medizinische Physik 2021, 31(4): 394-402; Magnetic Resonance in Medicine 2022, 87(5): 2099-2110 de_DE
utue.publikation.noppn yes de_DE


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