A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Roehlen, Natascha; Saviano, Antonio; El Saghire, Houssein; Crouchet, Emilie; Nehme, Zeina; Del Zompo, Fabio; Juehling, Frank; Oudot, Marine A.; Durand, Sarah C.; Duong, Francois H. T.; Cherradi, Sara; Motos, Victor Gonzalez; Almeida, Nuno; Ponsolles, Clara; Heydmann, Laura; Ostyn, Tessa; Lallement, Antonin; Pessaux, Patrick; Felli, Emanuele; Cavalli, Andrea; Sgrignani, Jacopo; Thumann, Christine; Koutsopoulos, Olga; Fuchs, Bryan C.; Hoshida, Yujin; Hofmann, Maike; Vyberg, Mogens; Viuff, Birgitte Martine; Galsgaard, Elisabeth D.; Elson, Greg; Toso, Alberto; Meyer, Markus; Iacone, Roberto; Schweighoffer, Tamas; Teixeira, Geoffrey; Moll, Solange; De Vito, Claudio; Roskams, Tania; Davidson, Irwin; Heide, Danijela; Heikenwaelder, Mathias; Zeisel, Mirjam B.; Lupberger, Joachim; Mailly, Laurent; Schuster, Catherine; Baumert, Thomas F.

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Author:

Roehlen, Natascha; Saviano, Antonio; El Saghire, Houssein; Crouchet, Emilie; Nehme, Zeina; Del Zompo, Fabio; Juehling, Frank; Oudot, Marine A.; Durand, Sarah C.; Duong, Francois H. T.; Cherradi, Sara; Motos, Victor Gonzalez; Almeida, Nuno; Ponsolles, Clara; Heydmann, Laura; Ostyn, Tessa; Lallement, Antonin; Pessaux, Patrick; Felli, Emanuele; Cavalli, Andrea; Sgrignani, Jacopo; Thumann, Christine; Koutsopoulos, Olga; Fuchs, Bryan C.; Hoshida, Yujin; Hofmann, Maike; Vyberg, Mogens; Viuff, Birgitte Martine; Galsgaard, Elisabeth D.; Elson, Greg; Toso, Alberto; Meyer, Markus; Iacone, Roberto; Schweighoffer, Tamas; Teixeira, Geoffrey; Moll, Solange; De Vito, Claudio; Roskams, Tania; Davidson, Irwin; Heide, Danijela; Heikenwaelder, Mathias; Zeisel, Mirjam B.; Lupberger, Joachim; Mailly, Laurent; Schuster, Catherine; Baumert, Thomas F.

Tübinger Autor(en):

Heikenwälder, Mathias

Published in:

Science Translational Medicine (2022), Bd. 14 (676), Article eabj4221

Verlagsangabe:

Amer Assoc Advancement Science

Language:

English

Full text:

http://dx.doi.org/10.1126/scitranslmed.abj4221

ISSN:

1946-6234