Depicting Transcranial Magnetic Stimulation from a Neuronal Perspective

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dc.contributor.advisor Bartels, Andreas (Prof. Dr.)
dc.contributor.author Li, Bingshuo
dc.date.accessioned 2022-12-21T14:07:57Z
dc.date.available 2022-12-21T14:07:57Z
dc.date.issued 2022-12-21
dc.identifier.uri http://hdl.handle.net/10900/134556
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1345564 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-75907
dc.description.abstract Transcranial magnetic stimulation (TMS) is a widely used non-invasive tool to study and modulate human brain functions. However, our knowledge of TMS neurophysiology is largely limited due to various difficulties in studying neural activities in vivo in real-time under the strong electromagnetic interference generated by TMS. In this work, the author first reviews the state-of-the-art knowledge in the neurophysiology of TMS and highlights the need to conduct further studies at the level of individual neurons and their neural networks. The second chapter is dedicated to the technical development of a research platform that allows faithful concurrent TMS and EEP recording in laboratory rodents. Building on this methodology, the third chapter focuses on characterizing the dynamics of neuronal activities in M1 evoked by a monophasic single-pulse TMS (mspTMS) that triggers unilateral MEPs in the forearm. Bringing the investigation further, the fourth chapter explores the mechanism of TMS-evoked intermediate excitation, a period of synaptic-mediated excitatory neuronal activities in M1 triggered by TMS, in the cortico-basal ganglia-thalamo-cortical (CBGTC) and the cortico-cerebello-thalamo-cortical (CCTC) loop. Finally, the fifth chapter summarizes the results from this work, discusses their limitations and implications, and proposes future research. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.classification brain stimulation , neurology , neuroscience de_DE
dc.subject.ddc 000 de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.subject.ddc 610 de_DE
dc.subject.other TMS de_DE
dc.subject.other Neurostimulation de_DE
dc.subject.other TMS en
dc.subject.other Transkranielle Magnetstimulation de_DE
dc.subject.other Brain stimulation en
dc.subject.other Transcranial Magnetic Stimulation en
dc.subject.other Gehirnstimulation de_DE
dc.title Depicting Transcranial Magnetic Stimulation from a Neuronal Perspective en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2022-11-18
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.noppn yes de_DE

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