Functional MRI for the early detection of Parkinson’s disease: ROI analysis of the putamen in a population at risk of developing Parkinson’s disease

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dc.contributor.advisor Berg, Daniela (Prof. Dr.)
dc.contributor.author Binder, Tobias
dc.date.accessioned 2022-05-12T13:18:39Z
dc.date.available 2022-05-12T13:18:39Z
dc.date.issued 2022-05-12
dc.identifier.uri http://hdl.handle.net/10900/127022
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1270220 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-68385
dc.description.abstract Background: While the concept of prodromal Parkinson’s disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connectivity of the putamina in a resting-state functional MRI analysis in persons with at least two prodromal factors for PD, which is considered a high risk for PD (HRPD) group, in comparison to PD patients and controls. Methods: We included 16 PD patients, 20 healthy controls and 20 HRPD subjects. Resting state echo planar images and anatomical T1-weighted images were acquired with a Siemens Prisma 3 Tesla scanner. The computation of correlation maps of the left and the right puta-men to the rest of the brain was done in a voxel-wise approach using the REST toolbox. Finally, group differences in the correlation maps were compared on voxel-level and summarized in cluster z-statistics. Results: Compared to both PD patients and healthy controls, the HRPD group showed higher functional connectivity of both putamina to brain regions involved in execution of motion and coordination (cerebellum, vermis, pre- and postcentral gyrus, supplementary motor area) as well as the planning of movement (precuneus, cuneus, superior medial frontal lobe). Conclusions: Higher functional connectivity of the putamina of HRPD subjects to other brain regions involved in motor execution and planning may indicate a compensatory mechanism. Follow-up evaluation and independent longitudinal studies should test whether our results re-flect a dynamic process associated with a prodromal PD state. de_DE
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.ddc 610 de_DE
dc.subject.other neurology en
dc.subject.other parkinson en
dc.subject.other fMRI en
dc.subject.other prodromal en
dc.subject.other putamen en
dc.title Functional MRI for the early detection of Parkinson’s disease: ROI analysis of the putamen in a population at risk of developing Parkinson’s disease en
dc.type Dissertation de_DE
dcterms.dateAccepted 2021-08-26
utue.publikation.fachbereich Medizin de_DE
utue.publikation.fakultaet 4 Medizinische Fakultät de_DE
utue.publikation.noppn yes de_DE

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