Assessing the role of arousal state in sensorimotor gating and memory consolidation

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dc.contributor.advisor Logothetis, Nikos (Prof. Dr.) Yang, Mingyu 2022-02-04T12:30:59Z 2022-02-04T12:30:59Z 2023-11-29
dc.identifier.uri de_DE
dc.description.abstract The brain state is a recurring, temporally enduring constellation of neural activity. It varies with or without external stimuli to both spatial and temporal extent. Brain state can be characterized in various dimensions, such as arousal, affective, cognitive, exploratory, and many others. Among them, the arousal state is the most well‐studied one. Neural activities that support sensory processing, motor control, decision making, mnemonic function are all influenced by the ongoing arousal level. However, the modulation of arousal state on different aspects of brain functions and behavioral outputs remains largely unexplored. In my Ph.D. work, I investigated the sensorimotor gating and memory consolidation across different arousal states, measured by the frontal electroencephalogram (EEG) and concurrently recorded animals' movements. Acoustic startle response (ASR) and prepulse inhibition (PPI) were used to assess the sensorimotor function (Manuscript 1). To manipulate the arousal level, we delivered electrical micro‐stimulation pulses to the locus coeruleus (LC), the nucleus that sends brain‐wide projections and regulates arousal via releasing noradrenaline (NA) in the target brain regions. We observed that the magnitude of the startle response was significantly reduced by increasing cortical arousal effectively with phasic LC activation. Next, by examining startle response across spontaneous fluctuations of arousal levels, we found that the smallest startle response during the active awake state, further suggesting that arousal states modulated ASR amplitudes. To study memory consolidation, we selected a well‐studied hippocampal neural event, sharp wave‐ripple (SPW‐R), which is essential for various memory functions. We characterized neuronal activity in the LC (Manuscript 2) and mediodorsal thalamus (MD, Manuscript 3) through multi‐site electrophysiological recordings around SPW‐Rs during quiet awake state and slow wave sleep. Overall, we observed suppressions of both LC and MD spiking activity around SPW‐Rs. The SPW‐R‐associated suppression in both structures differed across arousal states, being strongest and the most consistent during awake ripples. Taken together, these results showed that the fluctuation of the arousal state could modulate neural activity and behavioral output, including both the basic motor reflex and higher cognitive function, in this case, memory consolidation. The engagement of neural circuits and cross‐regional communications in the same behavioral context highly depends on the ongoing background brain activity. en
dc.description.abstract Dissertation ist gesperrt bis zum 29.11.2023 !! de_DE
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.subject.other Arousal en
dc.subject.other Memory consolidation en
dc.subject.other Prepulse inhibition en
dc.subject.other Locus coeruleus en
dc.subject.other Sharp‐wave ripple en
dc.subject.other Sleep spindle en
dc.subject.other Mediodorsal thalamus en
dc.title Assessing the role of arousal state in sensorimotor gating and memory consolidation en
dc.type Dissertation de_DE
dcterms.dateAccepted 2021-11-29
utue.publikation.fachbereich Biologie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.source Yang, M., Logothetis, N. K., & Eschenko, O. (2021). Phasic activation of the locus coeruleus attenuates the acoustic startle response via increasing cortical arousal. Scientific Reports, 11(1), 1‐14;Yang, M., Logothetis, N. K., & Eschenko, O. (2019). Occurrence of hippocampal ripples is associated with activity suppression in the mediodorsal thalamic nucleus. Journal of Neuroscience, 39(3), 434‐444. de_DE
utue.publikation.noppn yes de_DE


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