Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action

Korff, Marvin; Imberg, Lukas; Will, Jonas M.; Bueckreiss, Nico; Kalinina, Svetlana A.; Wenzel, Benjamin M.; Kastner, Gregor A.; Daniliuc, Constantin G.; Barth, Maximilian; Ovsepyan, Ruzanna A.; Butov, Kirill R.; Humpf, Hans-Ulrich; Lehr, Matthias; Panteleev, Mikhail A.; Poso, Antti; Karst, Uwe; Steinmetzer, Torsten; Bendas, Gerd; Kalinin, Dmitrii, V

Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action

Author:

Korff, Marvin; Imberg, Lukas; Will, Jonas M.; Bueckreiss, Nico; Kalinina, Svetlana A.; Wenzel, Benjamin M.; Kastner, Gregor A.; Daniliuc, Constantin G.; Barth, Maximilian; Ovsepyan, Ruzanna A.; Butov, Kirill R.; Humpf, Hans-Ulrich; Lehr, Matthias; Panteleev, Mikhail A.; Poso, Antti; Karst, Uwe; Steinmetzer, Torsten; Bendas, Gerd; Kalinin, Dmitrii, V

Tübinger Autor(en):

Poso, Antti

Published in:

Journal of Medicinal Chemistry (2020), Bd. 63, H. 21, S. 13159-13186

Verlagsangabe:

Amer Chemical Soc

Language:

English

Full text:

http://dx.doi.org/10.1021/acs.jmedchem.0c01635

ISSN:

1520-4804