Development of bispecific antibodies with optimized T cell costimulatory activity

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dc.contributor.advisor Jung, Gundram (Prof. Dr.)
dc.contributor.author Manz, Timo
dc.date.accessioned 2021-02-22T07:58:34Z
dc.date.available 2021-02-22T07:58:34Z
dc.date.issued 2022-10-19
dc.identifier.uri http://hdl.handle.net/10900/112777
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1127770 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-54153
dc.description.abstract In recent years, the clinical application of therapeutic antibodies has already significantly improved the therapy and prognosis of various malignant diseases. Notably, immunomodulating antibodies demonstrated the possibility to selectively modify the T cell-response and thus represent an attractive therapeutic strategy. However, in many cases, the therapeutic success of monospecific antibodies is limited or comes with severe systematic side-effects in patients. In comparison, the use of bispecific antibodies demonstrated several advantages by enabling the recruitment and activation of effector cells such as T cells, specifically at the tumor side. This thesis presents the in-vitro generation, characterization, and optimization of novel immunomodulating bispecific antibodies for target cell-restricted modulation of T cell activation. The bispecific antibodies were subjected to an extensive characterization process aiming at the identification of the optimal antibody format and clone. Finally, secondary work focused on a successful humanization by CDR grafting to decrease the risk of immunogenicity. Taken together, certain immunomodulating antibodies described in this work demonstrated a beneficial effect on activated T cells only in a target cell-restricted manner and demonstrate the potential of a novel promising therapeutic candidate for selective cancer treatment. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en en
dc.subject.classification Antikörper , Immunologie , Immunbiologie , Tumorimmunologie , Immuntherapie , Proteindesign de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.subject.other bispezifische Antikörper de_DE
dc.subject.other bispecific antibodies en
dc.subject.other therapeutische Antikörper de_DE
dc.subject.other immunology en
dc.subject.other Antibody engineering en
dc.subject.other antibody en
dc.title Development of bispecific antibodies with optimized T cell costimulatory activity en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2020-10-19
utue.publikation.fachbereich Biologie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.noppn yes de_DE

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