Adenosine and its Impact on Neonatal Immune Effector Cells

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dc.contributor.advisor Gille, Christian (PD Dr.) Ďurčo, Filip 2021-02-02T09:05:56Z 2021-02-02T09:05:56Z 2022-11-27
dc.identifier.uri de_DE
dc.description.abstract Neonatal sepsis is a leading cause of neonatal morbidity and mortality. This is partially due to immaturity of the neonatal immune system as a remnant of prenatal development when the activity of neonatal immune system has to be downregulated and feto-maternal tolerance has to be maintained. Postnatally, the switch from immunosuppression to immunocompetence may be delayed because of persisting cellular mechanisms acting inhibitory such as presence of myeloid-derived suppressor cells (MDSC), as well as soluble factors. In adults extracellular adenosine has been shown to act immunosuppressive. In this project, the role of adenosine for neonatal immunosuppression was analyzed. The role of adenosine in neonates is only incompletely understood. My results show that adenosine is produced by neonatal immune effector cells and that it can inhibit neonatal immune reactions either directly through T cell proliferation inhibition or indirectly via MDSC induction and their activation by induction of indoleamine-2,3-dioxygenase (IDO) production. Pleiotropism of adenosine may therefore be one of the key players in the maintaining of feto-maternal tolerance and neonatal immunosuppression. According to the results of my investigations, adenosine may be a promising target for immunotherapy in the neonate. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Neugeborenensepsis de_DE
dc.subject.ddc 500 de_DE
dc.subject.other neonatal immune system en
dc.subject.other Myeloid-derived suppressor cells en
dc.title Adenosine and its Impact on Neonatal Immune Effector Cells en
dc.type Dissertation de_DE
dcterms.dateAccepted 2020-11-27
utue.publikation.fachbereich Biochemie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.noppn yes de_DE


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