Influence of the murine transcription factor SRF on mural cell regulated retinal angiogenesis

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Influence of the murine transcription factor SRF on mural cell regulated retinal angiogenesis

Orlich, Michael
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Description: Dissertation Michael ...
URI: http://hdl.handle.net/10900/109968
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1099685
http://dx.doi.org/10.15496/publikation-51344
Dokumentart: Dissertation
Date: 2022-11-17
Language: English
Faculty: 7 Mathematisch-Naturwissenschaftliche Fakultät
Department: Biologie
Advisor: Nordheim, Alfred (Prof. Dr.)
Day of Oral Examination: 2020-11-17
DDC Classifikation: 570 - Life sciences; biology
Keywords: Angiogenese , Netzhaut , Mikroskopie , Transkriptionsfaktor
Other Keywords: Perizyten
Glattmuskelzellen
Serum Response Factor
retina
pericytes
angiogenesis
smooth muscle cells
serum response factor
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Abstract:

Serum Response Factor (SRF) is a ubiquitously expressed transcription factor that regulates the transcription of about 1000 target genes. Endothelial cell (EC)-specific depletion of SRF was previously shown to cause the formation of hemorrhages in the neonatal murine brain and microaneurysms in the retina. However, the physiological role of SRF in mural cells (MCs) remains unknown. MCs wrap around blood vessels and play important roles in angiogenesis, vessel stabilization and homeostasis of the vasculature. They are essential to maintain the integrity of the blood brain barrier and play significant roles in numerous diseases. To investigate the role of SRF in MCs, Srf-flex1::Pdgfbr-CreERT2 mice were established, which allow tamoxifen inducible, MC-specific Srf deletion (namely SrfiMCKO) and the consequences of this Srf deletion were investigated in the postnatal mouse retina.

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