Genomic Insights into Late Neolithic and Early Bronze Age Populations of Modern-Day Switzerland

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dc.contributor.advisor Krause, Johannes (Prof. Dr.) Furtwängler, Anja 2020-10-19T07:44:28Z 2020-10-19T07:44:28Z 2020-10-19
dc.identifier.other 1735942111 de_DE
dc.identifier.uri de_DE
dc.description.abstract aDNA research on human remains provides great opportunities to study past populations regarding their genetic history and processes that shaped modern-day populations. The topic of this dissertation was to further improve specific techniques for aDNA analysis, such as specific target enrichment and authentication of the retrieved sequences, and to use these improved methods to investigate the population history of modern-day Switzerland. In the first paper, issues in estimating contamination were addressed which represents a major problem in aDNA research. The level of contaminating DNA in the mtDNA can easily be assessed but this estimate might not be representative in case of extreme differences between the amount of mtDNA and nDNA. In this study, it is shown that petrous bones contain more nuclear DNA in relation to their mitochondrial DNA content and that this causes the mitochondrial and nuclear contamination rates to be most similar. In the second study, different methods for specific target enrichment were compared to determine the most efficient one. Statistical analyses were used to compare their performance regarding enrichment efficiency, specificity, and reproducibility. Results indicate that the commercial myBaits® kit utilising RNA baits is the most suitable for the work on aDNA and that in-solution approaches, in general, are advantageous. The third study focuses on the genetic transitions detected in the 5th millennium BP in Europe and particularly in modern-day Switzerland. The main aspects of the study are ancestry components, admixture dates, and social structure. In this study, results show that a steppe-like ancestry component arrives in Switzerland in around 4700 BP and that the relative amount decreases after a sudden steep increase. Furthermore, female individuals with relatively young radiocarbon dates but with zero steppe ancestry who were likely causing this decline could be identified. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Genetik , Schweiz , Alte DNA de_DE
dc.subject.ddc 500 de_DE
dc.subject.other ancient DNA en
dc.subject.other Switzerland en
dc.title Genomic Insights into Late Neolithic and Early Bronze Age Populations of Modern-Day Switzerland en
dc.type Dissertation de_DE
dcterms.dateAccepted 2020-10-09
utue.publikation.fachbereich Geographie, Geoökologie, Geowissenschaft de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE


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