The roles of NMDA- and GABA receptors for working memory activity in primate prefrontal cortex

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dc.contributor.advisor Nieder, Andreas (Prof. Dr.) Rodermund, Paul 2020-09-29T05:25:01Z 2020-09-29T05:25:01Z 2020-09-29
dc.identifier.other 1733901760 de_DE
dc.identifier.uri de_DE
dc.description.abstract The persistent activation of prefrontal neurons after a stimulus has disappeared is considered a neuronal correlate of working memory. Current explanations suggest that persistent activation during a delay depends on a delicate but poorly understood interplay between excitatory glutamatergic and inhibitory GABAergic receptor effects. We addressed the roles of these receptor systems directly by iontophoretically applying the NMDA receptor antagonist MK-801 and the GABA(A) receptor antagonist bicuculline methiodide while simultaneously recording extracellular activity in prefrontal cortex of monkeys performing a working memory task. Following a delay period monkeys had to decide whether they had previously seen a stimulus that was either absent or present at intensities close to perceptual threshold. The blockade of GABA(A) receptors strongly improved the stimulus selectivity of the neurons’ delay activity, causing an increase in signal to noise ratio during working memory periods as well as an enhancement of the neurons’ coding selectivity. The blockade of NMDA receptors resulted in a slight enhancement of stimulus selectivity and encoding capacity of the neurons. Inactivation of both NMDA- and GABA(A) receptors in the same individual neurons showed a similar enhancement of the neurons’ coding selectivity. Our findings emphasize the delicate and more complex than expected interplay of excitatory and inhibitory transmitter systems in modulating working memory coding in prefrontal circuits. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Präfrontaler Cortex , Arbeitsgedächtnis , Aminobuttersäure <gamma-> , NMDA de_DE
dc.subject.ddc 150 de_DE
dc.subject.ddc 570 de_DE
dc.subject.ddc 610 de_DE
dc.subject.other Neuroscience en
dc.subject.other Working memory en
dc.subject.other Glutamate en
dc.subject.other GABA en
dc.subject.other Prefrontal cortex en
dc.title The roles of NMDA- and GABA receptors for working memory activity in primate prefrontal cortex en
dc.type Dissertation de_DE
dcterms.dateAccepted 2020-02-21
utue.publikation.fachbereich Graduiertenkollegs de_DE
utue.publikation.fakultaet 9 Sonstige / Externe de_DE


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