I report on two class III ACs of Mycobacterium tuberculosis which possess very different structural as well as catalytic characteristics: the mammalian-like membrane-anchored Rv1625c and the transcription-factor-attached ...
The Mycobacterium tuberculosis genome has 15 open reading frames for class III adenylyl cyclases. Here I report on two structurally different ACs belonging to two different subclasses; the mammalian-like Rv2435c classified ...
In this thesis, a bead based multiplexed serological antigen assay was generated, optimized and validated for the detection of human antibodies in serum of patients infected with tuberculosis.
To ensure reliable and ...
Myeloid differentiation primary response 88 (MyD88) is the key adaptor protein that mediates signals upon activation of Toll-like receptors (TLR) and the IL-1 receptor (IL-1R). MyD88 consists of a Toll/IL-1R (TIR) domain ...