Severe congenital neutropenia (CN) is a pre-leukemia bone marrow failure syndrome with profoundly diminished terminal granulocytic differentiation of hematopoietic stem cells (HSCs). Life-long treatment with granulocyte-colony ...
Perfused bioreactor systems are considered to be a promising approach for the
3D culturing of stem cells by improving the quality of the tissue-engineered grafts
in terms of better cell proliferation and deeper penetration ...
FEA, based on a large amount of data from microscale image scanning and immense computing power, has shown great potential to simulate bone mechanics. This research intended to establish and validate FE models based on ...