2026-09-18T17:50:54Zhttps://publikationen.uni-tuebingen.de/oai/requestoai:publikationen.uni-tuebingen.de:10900/814612019-10-30T07:10:57Zcom_10900_42126col_10900_42130
Publikationssystem UB Tuebingen
advisor
Sharma, Manu
author
Wang, Lisa Yuan
2018-04-17T10:33:06Z
2018
506484688
http://hdl.handle.net/10900/81461
The discovery of new genetic risk factors through a range of methods over the years has resulted in a long list of genetic variants that influence PD risk. The incompleteness of the inheritance patterns and the limited ability (up to 10%) of the genetic variants to explain PD cases suggests complex and multifactorial origins for PD. The first part of the thesis addresses the etiological factor of protein aggregation through the question of cross-disease effect of ataxia genes on PD risk. The second part of the thesis takes the theme of aggregration but approaches it from the transportation pathways. Given the known functional interaction between two genes in the retromer pathway, we investigated a possible genetic interaction between the two previously identified risk modulating loci, PARK16 and LRRK2. Immune response and mitochondrial dysfunction drive the third part of the thesis; we investigated the differences in clinical outcomes between type 1 diabetic patients with PD and neurologically normal patients. Firstly, we conclude that SCA2,3,6 and 17 do not impact PD risk. Secondly, we demonstrated that LRRK2 and PARK16 do not interact on a statistically significant level. Thirdly, we showed a series of notable differences in the disease progression between PD patients and neurologically normal TD1 patients.
en
Genetic Risk Factors of Parkinson's disease
PhDThesis
URL
https://publikationen.uni-tuebingen.de/xmlui/bitstream/10900/81461/1/LWang_Thesis_2018.pdf
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LWang_Thesis_2018.pdf
URL
https://publikationen.uni-tuebingen.de/xmlui/bitstream/10900/81461/3/LWang_Thesis_2018.pdf.txt
File
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LWang_Thesis_2018.pdf.txt